Blood Sugar Testing - Blood Tests for Colitis and Crohn's Disease: an Introduction
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Antibody tests or serologic markers are blood tests finding for markers of diseases. The serologic markers or antibody tests for ulcerative colitis and Crohn's disease are pAnca and Asca, OmpC, and Cbir1 Flagelin respectively. The latter three blood tests for Crohn's are only ready straight through one laboratory, Prometheus Laboratories, Inc.
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Ulcerative colitis is a continuing inflammatory bowel disease (Ibd) of unknown cause that only involves the colon. It affects the superficial lining of the colon and rarely causes bowel obstruction (blockage) or perforation (rupture) but oftentimes causes severe bloody diarrhea, blood in the stool, weight loss, abdominal pain, as well as joint aches or arthritis, skin rashes, eye irritation and occasionally a severe liver disorder known as primary sclerosing cholangitis that can lead to cirrhosis and liver cancer. Ulcerative colitis can be cured by faultless discharge of the colon but not Crohn's disease.
Crohn's disease can also cause colitis but normally also affects the very end of the small intestine called the ileum (ileitis or regional enteritis). When Crohn's affects only the colon it may be difficult to distinguish it from ulcerative colitis though Crohn's tends to influence the colon in a patchy manner whereas ulcerative colitis is continuous. Crohn's can influence the gastrointestinal tract anywhere from the mouth to the anus and is not curable by removing the colon. It is also oftentimes related with bowel strictures (constrictions) causing obstruction that may want surgery. It also may be related with fistula that are abnormal connections of the intestine to other organs and the skin or it can follow in abscesses or perforation requiring surgery It is important to distinguish Crohn's disease from ulcerative colitis since medical treatments and surgical approaches may differ and the types of complications that can occur can be much different.
Traditionally, the analysis of ulcerative colitis and Crohn's disease is extremely accurate by the appearance of the colon on colonoscopy or x-rays that confirm the presence or absence of involvement of other parts of the intestinal tract. analysis is confirmed by a typical pattern of inflammation of the intestine lining as seen under the microscope on tissue obtained by biopsy while colonoscopy. However, before blood tests were ready about 10% of people with Ibd were diagnosed as having an indeterminate colitis because the biopsies could not distinguish in the middle of the ulcerative colitis and Crohn's disease.
Asca is anti-saccharomyces cerevisiae antibody. Saccharomyces cerevisiae is Brewer's or Baker's yeast. Crohn's patients have a high prevalence of abnormal antibodies to this yeast. Some have suggested that someone else yeast, Candida albicans, somehow plays a role in this abnormal response. A few people with celiac disease have this antibody gift in their blood in the absence of signs of Crohn's disease. OmpC is the abbreviation for an antibody that develops in many Crohn's patients to the outer membrane porin protein of the bacteria E. Coli though that bacteria is not opinion to be the cause of Crohn's disease. Just recently Prometheus Laboratories added antibody testing for a definite protein on bacteria that constitutes the flagelin or hair like buildings on inescapable bacteria enabling movement and attachment of bacteria in the intestine called Cbir1 flagelin.
Future blood tests may include antibodies against inescapable sugar (mannose) residues in the cell wall of the yeast saccharomyces cerevisiae. Anti-laminaribioside and anti-chitobioside antibodies were recently reported to be gift in Crohn's patients who were anti-Asca negative perhaps supplementary strengthening the ability to distinguish them from people with ulcerative colitis. This is also keen because of suspicions and the lay collective interest in the role of sugars or glycans and yeast in Ibd. In particular the reports in lay literature of success of carbohydrate definite diet in Ibd.
If you have a analysis of ulcerative colitis or Crohn's disease these blood tests may be very helpful in your treatment. If you have unexplained abdominal pain, diarrhea, or blood in your stools then these tests should be considered. If you have a analysis of irritable bowel syndrome, these tests may exclude ulcerative colitis and Crohn's disease. Since as many as 10% of people with ulcerative colitis and Crohn's disease may also have celiac disease, celiac blood tests should also be considered. Lactose intolerance is also common in Ibd, Ibs and celiac disease.
Future helpful information on colitis, Crohn's disease, celiac disease, food allergies, food intolerance, food sensitivity, eosinophilic esophagitis and irritable bowel syndrome will be ready from Dr. Scot Lewey, the food allergy expert-the food doc at http://www.thefooddoc.com. information on colitis and Crohn's disease can also be obtained from the Crohn's and Colitis Foundation of America (Ccfa, http://www.ccfa.org). Dr. Scot Lewey is a member of the medical advisory panel for the Rocky Mountain episode of Ccfa. For more information about Prometheus Laboratories Inc. See http://www.prometheuslabs.com. A more detailed explanation of the blood tests can be found in a cut off description by the food doc and references below.
Abreu Mt et.al. Use of Serologic Tests in Crohn's Disease. Clinical Gastroenterology and Hepatology. Vol.4, No. 3. 2001
Dotan I et.al. Antibodies Against Laminaribioside and Chitiobioside Are Novel Serologic Markers in Crohn's Disease. Gastroenterology. Vol.131, No. 2. 2006
Mei, L et.al. Familial Expression of Anti-Escherichia coli Outer Membrane Porin C in Relatives of Patients with Crohn's Disease. Gastroenterology. Vol. 130, No. 4 2006
Stadaert-Vitse et.al. Candida albicans Is an Immunogen for Anti-Saccharomyces cerevisiae Antibody Markers of Crohn's Disease. Gastroenterology. Vol 130, No. 6. 2006
Targan, Sr et.al. Antibodies to Cbir1 Flagelin Define a Unique Response That Is related Independently Crohn's Disease. Gastroenterology. Vol.128, No.7. 2005
Copyright The Food Doc, Llc, 2006. All ownership Reserved. Http://www.thefooddoc.com
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